Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease

Multichain Immune Recognition Receptors (MIRRs) represent a family of surface receptors expressed on different cells of the hematopoietic system and function to transduce signals leading to a variety of biologic responses. These receptors share common structural features including extracellular ligand-binding domains and intracellular signaling domains intriguingly carried on separate subunits. Another important feature that links members of the MIRRfamily is the presence of one or more copie…